Introduction. Chinesemedicine syndrome diagnosis is the key requisite in the treatment of male infertility with traditional Chinese\nmedicine (TCM). Kidney-Yang deficiency syndrome (KYDS) is the critical Chinese medicine syndrome of male infertility. To\nexplore the modernized mechanisms of KYDS in male infertility, this study aims to investigate the metabolomics of males with\nKYDS. Methods. The gas chromatography-mass spectrometry method was applied to analyze the plasma samples of 67 infertile\nmales with KYDS compared with 55 age-matched healthy controls. The chemometric methods including principal component\nand partial least squares-discriminate analyses were employed to identify the potential biochemical patterns.With the help of the\nvariable importance for the projection and receiver operating characteristic curve analyses, the potential biomarkers were extracted\nto define the clinical utility. Simultaneously the high-quality KEGG metabolic pathways database was used to identify the related\nmetabolic pathways. Results. The metabolomics profiles of infertile males with KYDS including 10 potential biomarkers and six\nmetabolic pathways were identified. They precisely distinguished infertile males with KYDS from healthy controls. Conclusions.\nThese potential biomarkers and pathways suggest the substantial basis of infertile males with KYDS. The metabolomics profiles\nhighlight the modernized mechanisms of infertile males with KYDS.
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